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Synthesis of Monastrol
Application Fields
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Organic Synthesis
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Pharma
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OnePot Gain
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x500 scaleup
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Reaction efficency comparable to MW
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Translated in 5 WDs
Monastrol has been synthesised by Biginelli reaction following an MW-assisted protocol previously reported by Kappe et al. The multicomponent reaction between thiourea, 3-OH-benzaldehyde, and ethylacetoacetate is catalysed by Yt(OTf)3 under MW heating at 120°C for 30 min. Compared to classical protocols, MW heating is an instant on-off internal heating system that reduces reaction time and byproducts. Matrix-in-batch technology, implemented by OnePot, is comparable to MW in terms of efficiency on a bigger scale.
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